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Esterification Response: This response is important for forming the Original precursor wanted for even more modifications.
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Reduction: This intermediate is then reacted with formaldehyde and sodium triacetoxyborohydride in acetonitrile to generate Yet another intermediate.
Relevance: DAMGO is used for just a reference overall agonist in scientific reports investigating the phosphorylation profiles of MOR. Even though both equally of These DAMGO and SR-17018 induce MOR phosphorylation, they exhibit exceptional temporal dynamics, with SR-17018 inducing prolonged phosphorylation. [
Research System: As staying a biased agonist, SR17018 serves like a helpful exploration Instrument for Understanding mu-opioid receptor signaling pathways and comprehension biased signaling mechanisms.
Deprotection: The ultimate phases include deprotection applying hydrazine hydrate and crystallization to isolate the specified solution